Team : Efficacy and Resistence to anti-tumor targeted therapies

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Molecular Oncology, 2024

http://doi.org/10.1002/1878-0261.13739

The MET receptor activation pathway is intrinsically linked to the activity of the transcription factors ETV1 and ERG (ETS family) to promote tumorigenesis in prostate cancer cells.

Here we focus on the transcriptional programme leading to this partnership and have identified 5 commonly regulated target genes that may represent a potential signature of prostate cancer progression at advanced stages.

Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression.

Carouge E, Burnichon C, Figeac M, Sebda S, Vanpouille N, Vinchent A, Truong MJ, Duterque-Coquillaud M, Tulasne D, Chotteau-Leliévre  A.

Molecular Oncology, 2024

http://doi.org/10.1002/1878-0261.13739