News

CANTHER awardee of the Fondation ARC – SIGN’IT 2020 – Signatures en immunothérapie – diagnostiquer, prédire et suivre la réponse au traitement

Dr Suman MITRA of CANTHER team”Factors of persistence of leukemic cells” is awardee of the Fondation ARC call – SIGN’IT 2020 – Signatures en immunothérapie – diagnostiquer,
prédire et suivre la réponse au traitement on the project « Synergy between synthetic CAR T cell and endogenous T cell immunity against tumor cells in  B-cell
lymphomas ». This project (600 000 €) in collaboration with Pr Franck MORSCHHAUSER, hematologist at Lille hospital (CHU de Lille),  will allow studies on CAR-T biomarkers in lymphoma.

News

CANTHER’s researchers filed a PATENT (N° EP3766544A1) on anti-PD-1/PD-L1 small molecules

Bruno Quesnel and Xavier Thuru (Team “Factors of persistence of leukemic cells” ) have developed small molecules that block the interaction between PD-L1/PD-1 to allow the restoration of the host’s antitumor immune response against dormant tumor cells and more generally to tumors in which PD-L1 participate in immuno-escape.

Pyrazolone derivatives have been identified as having a strong blocking potential of the different interactions between PD-L1/PD-1.  These molecules are aimed to be used to block immuno-escape mechanisms in patients in cancer remission, allowing eradication or at least long-term control of minimal residual disease.

News

CANTHER awardee of the call flash Fondation ARC Cancer & COVID-19.

Dr Martine Duterque-Coquillaud is awardee of the Fondation ARC flash call on Cancer & COVID-19. She studies the relationship betweenprostate cancer and Covid-19: the role of androgens in the regulation of TMPRSS2 expression, key protease in SARS-CoV-2 virus infection.

Expected results: assist in establishing a possible link between androgens and Covid-19, in vitro and in vivo, while also helping to anticipate the risk and severity for patients with prostate cancer depending on whether they are or not treated with hormone therapy.
Project impact: at a cognitive level, understand one of the possible roles of androgens in viral infection in men. At a clinical level, optimize the management of prostate cancer patients.