Team : Efficacy and Resistance to anti-tumor targeted Therapies

Team : Efficacy & Resistance to anti-tumor targeted Therapies

NEWS

The MET receptor activation pathway is intrinsically linked to the activity of the transcription factors ETV1 and ERG (ETS family) to promote tumorigenesis in prostate cancer cells.

Here we focus on the transcriptional programme leading to this partnership and have identified 5 commonly regulated target genes that may represent a potential signature of prostate cancer progression at advanced stages.

Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression. Carouge E, Burnichon C, Figeac M, Sebda S, Vanpouille N, Vinchent A, Truong MJ, Duterque-Coquillaud M, Tulasne D, Chotteau-Leliévre  A.

Molecular Oncology, 2024, http://doi.org/10.1002/1878-0261.13739

 

 

Presentation

Target Team : Efficacy and Resistence to anti-tumor targeted therapies, David Tulasne

Emergent Team : Molecular Therapeutic Approaches for Genetic Diseases and Cancer, Fabrice Lejeune  https://nonsense.univ-lille.fr/

 

Presentation : Target team

Targeted therapies are currently transforming cancer management and improving life expectancy. Their effectiveness relies on oncogenic addiction, where cancer cells survival and/or growth depend on a single oncogene, often tyrosine kinase receptors (RTKs). Among these, MET is a promising target, with tyrosine kinase inhibitors (TKIs) approved for the treatment of lung cancer. However, their efficacy is limited compared to other targeted therapies.

Our goal is to improve therapies targeting MET through three main areas:

• understanding the mechanisms of oncogenic addiction
• identifying resistance mechanisms
• expanding patient eligibility for targeted therapies.

To achieve this, our team focuses on lung and prostate cancers, the main causes of cancer mortality. Our research provides fundamental knowledge on oncogenic addiction and proposes new therapeutic strategies.

We have deliberately chosen to develop translational research and to work closely with molecular biologists, pathologists and clinicians at the CHU, who are directly involved in patient care.

We are constantly looking for Master students, PhD students, post-doc fellows or colleagues who would be interested in joining us to participate in the development of our research projects.

 

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STAFF

RESEARCHERS

	David TULASNE – Research Director (DR2) INSERM Research: Involvement of the MET receptor tyrosine kinase in cancers. Keywords: Receptor tyrosine kinase, Intracellular signaling, Tumor suppressor genes, Survival/apoptosis balance, Transcriptional regulation, lung Cancer, Targeted therapies, Resistance. david.tulasne@cnrs.fr
	Martine DUTERQUE-COQUILLAUD – Research Director (DR2) CNRS Research: ETS fusions in prostate cancer and metastasis formation. Keywords: Prostate cancer, Bone metastasis, ETS fusion, Transcriptional regulation. martine.duterque@cnrs.fr
	Anne CHOTTEAU-LELIEVRE – Professor (PR2) University of Lille Research: Cooperation between MET receptor and ETS fusions in prostate cancer progression Teaching: Molecular Biology, Genetic, Cellular Biology. Teaching responsibilities: Headmaster of Biotechnologies Master – Headmaster of “Cursus Master Ingénierie « Biotechnologies-Bioingénierie”. Keywords: Cancer, Prostate, ETS transcription factors, MET Receptor, Transcriptionnal regulation. anne.chotteau@univ-lille.fr
	Zoulika KHERROUCHE – Researcher (CR1) Institut Pasteur de Lille Research: Mechanisms of resistance to targeted therapies and innovative therapeutic approaches. Keywords: Receptor tyrosine kinase, Intracellular signaling, tumor suppressor genes, Survival/apoptosis balance, Transcriptional regulation, lung Cancer, Targeted therapies, Resistance. zoulika.kherrouche@cnrs.fr
	Dr Marie José TRUONG, Researcher, (CR1) Institut Pasteur de Lille Keywords: Murine model of breast cancer, tumoral microenvironment, immune cells, tumor-infiltrating lymphocytes (TILs). Teaching: Creation and supervision of the “Scientific Teachings” department at Pasteur Institute of Lille. Accreditation of Education and Training Courses in Laboratory Animal Science. marie-jose.truong@cnrs.fr
	Fabrice LEJEUNE – Researcher (DR2) INSERM https://nonsense.univ-lille.fr/ Research: Correction of nonsense mutations and study of the mechanisms leading to the recognition of premature termination codons. Keywords: nonsense mutations, nonsense-mediated mRNA decay (NMD, readthrough, targeted therapeutic approaches, screening, genetic diseases. fabrice.lejeune@inserm.fr
	Edith BONNELYE – Researcher DR2 CNRS edith.bonnelye@inserm.fr
	Marie-Hélène VIEILLARD – Onco-Rhumatologist (PH) COL and CHU Lille marie-helene.vieillard@chu-lille.fr
	Sarah HUMEZ – Anatomo-Pathologist (PH) CHU Lille sarah.humez@chu-lille.fr
	Arnauld VILLERS – Urologist – Professor (PU-PH) CHU Lille Keywords: Prostate Cancer, Screenin,. Diagnosis, MRI, Morphometry, Factors for progression, Histological Grade, Metastases. arnauld.villers@chu-lille.fr
	Xavier LEROY – Anatomo-Pathologist – Professor (PU-PH) CHU Lille xavier.leroy@chu-lille.fr
	Alexis CORTOT – Pneumologist – Professor (PU-PH) CHU Lille alexis.cortot@chu-lille.fr
	Jonathan OLIVIER – MCU-PH-MD-PhD, Urologist CHU Lille jonathan.olivier@chu-lille.fr
	Marie FERNANDES – PhD student University of Lille Involvement of MET alterations in lung cancer.marie.fernandes(@)ibl.cnrs.fr

ENGINEERS/TECHNICIANS

	Catherine AMPEN-GUFFROY – Engineer (IE) CNRS Molecular and Cellular Biology, Biochemistry, Bioinformatics, Animal experimentation, Health and safety (radiation protection advisor) catherine.leroy@cnrs.fr
	Gaëlle REMY –  Ingénieure CNRS –Chargée de projets réglementaires des expérimentations in vivo. gaelle.remy@cnrs.fr
	Nathalie VANPOUILLE – Technician (TL4) Institut Pasteur de Lille Cell culture, Molecular biology, Biochemistry, Cell imaging. nathalie.vanpouille@cnrs.fr
	Isabelle DAMOUR – Technician (TL4) Institut Pasteur de Lille Cell culture, Biochemistry, Molecular biology, L3 laboratory. isabelle.damour@cnrs.fr
	Audrey VINCHENT – Technician (TL2) Institut Pasteur de Lille Biochemistry, Molecular biology, Animal studies, Cell culture, Cellular biology audrey.vinchent@cnrs.fr
	Edwina GBAGUIDI-MICOURS – IE INSERM – CCD Biochimie, Biologie moléculaire et cellulaire, Expérimentation in vivo.edwina.micours@univ-lille.fr
	Lucie GEOFFROY, IE INSERM – CDD   lucie.geoffroy@inserm.fr

STUDENTS

	Rémy TELLIER, PhD student, Univ. Lille remi.tellier.etu@univ-lille.fr
	Maram ROUIS, PhD student Univ. Lille maram.rouis.etu@univ-lille.fr
	Léa BOUVIGNIES, PhD student Univ. Lille lea.bouvignies2.etu@univ-lille.fr
	Camille ORANGE, Master2 Recherche, Univ. Lille camille.orange@pasteur-lille.fr
	Thomas AMOUYEL, MD, PhD Student Univ. Lille Thomas.AMOUYEL@chu-lille.fr
	Denis SEGUIER, MD, PhD student Univ. Lille denis.seguier@chu-lille.fr
	Gautier MARCQ – MCU-PH – MD – Urologist Gautier.MARCQ@chu-lille.fr

Former members

	Anthony TURPIN – MD-PhD, Oncologist CHU Lille Medical Oncologist –  Urologic and GI cancers –  anthony.turpin@chu-lille.fr
	Aline GHESQUIER – PhD Univ. Lille Cancer de la prostate et Covid-19 : rôle des androgènes dans la régulation de l’expression de TMPRSS2, protéase majeure dans l’infection virale au SARS-CoV-2 aline.hantute-ghesquier@cnrs.fr
	Martine PALMA – PhD student University of Lille Involvement of novel proteins in the Nonsense-mediated mRNA decay (NMD) – martine.palma@cnrs.fr
	Julie CARRARD – Postdoc julie.carrard@cnrs.fr
	Anne-Claire FLOURENS – Technician (TCE) INSERM Molecular biology, Biochemistry, Histology – anne.flourens@cnrs.fr
	Célia GUERIN – PhD celia.guerin@etu.umontpellier.fr
	Elisa CAROUGE – PhD University of Lille elisa.carouge@cnrs.fr
	Pauline PARENT – MD – Master2 Student University of Lille pauline.parent@chu-lille.fr
	Philippe JAMME – MD, PhD Univ. Lille Etude des mécanismes de résistance aux inhibiteurs tyrosine kinase dans les cancers pulmonaires porteurs d’une addiction oncogénique. Philippe.JAMME@CHU-LILLE.FR
	Angela MORABITO – Engineer (IE) CDD CNRS Cellular biology, Molecular biology, Animal studies, Histology.angela.morabito@cnrs.fr
	Louise KALMUK – Master2 Student University of Lille MET mutations as resistance to EGFR inhibitors in lung cancer – louise.kalmuk@cnrs.fr
	Sonia PAGET – Engineer (IE) CCD CNRS Biochemistry, Molecular biology, Cell culture and Incucyte (cell proliferation, cell migration, wound healing and spheroids).sonia.paget@cnrs.fr

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RESEARCH Themes

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Scientific production

2024

Carouge E, Burnichon C, Figeac M, Sebda S, Vanpouille N, Vinchent A, Truong MJ, Duterque-Coquillaud M, Tulasne D, Chotteau-Leliévre  A. Functional interaction between receptor tyrosine kinase MET and ETS transcription factors promotes prostate cancer progression. Molecular Oncology, 2024, PMID: 39374163, http://doi.org/10.1002/1878-0261.13739 

Guérin C, Tulasne D. Recording and classifying MET receptor mutations in cancers. Elife. 2024 Apr 23;13:e92762. doi: 10.7554/eLife.92762. PMID: 38652103 Free PMC article. Review.

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2023

Turpin A, Delliaux C, Parent P, Chevalier H, Escudero-Iriarte C, Bonardi F, Vanpouille N, Flourens A, Querol J, Carnot A, Leroy X, Herranz N, Lanel T, Villers A, Olivier J, Touzet H, de Launoit Y, Tian TV, Duterque-Coquillaud M. Fascin-1 expression is associated with neuroendocrine prostate cancer and directly suppressed by androgen receptor. Br J Cancer. 2023 Dec;129(12):1903-1914. doi: 10.1038/s41416-023-02449-x. Epub 2023 Oct 24. PMID: 37875732

Dehem A, Mazieres J, Chour A, Guisier F, Ferreira M, Boussageon M, Girard N, Moro-Sibilot D, Cadranel J, Zalcman G, Ricordel C, Wislez M, Munck C, Poulet C, Gauvain C, Descarpentries C, Wasielewski E, Cortot AB, Baldacci S. Characterization of 164 patients with NRAS mutated non-small cell lung cancer (NSCLC). Lung Cancer. 2023 Oct 9;186:107393. doi: 10.1016/j.lungcan.2023.107393. Online ahead of print.PMID: 37839252

Chour A, Denis J, Mascaux C, Zysman M, Bigay-Game L, Swalduz A, Gounant V, Cortot A, Darrason M, Fallet V, Auclin E, Basse C, Tissot C, Decroisette C, Bombaron P, Giroux-Leprieur E, Odier L, Brosseau S, Creusot Q, Gueçamburu M, Meersseman C, Rochand A, Costantini A, Gaillard CM, Wasielewski E, Girard N, Cadranel J, Lafitte C, Lebossé F, Duruisseaux M. Brief Report: Severe Sotorasib-Related Hepatotoxicity and Non-Liver Adverse Events Associated With Sequential Anti-Programmed Cell Death (Ligand)1 and Sotorasib Therapy in KRAS^G12C-Mutant Lung Cancer. J Thorac Oncol. 2023 Oct;18(10):1408-1415. doi: 10.1016/j.jtho.2023.05.013. Epub 2023 May 20. PMID: 37217096.

Khiter F, Kherrouche Z, Dubois V, Slupek S, Petit E, Debrie AS, Cauchi S, Barois N, Rouanet C, Mielcarek N. Combined regulation of pro-inflammatory cytokines production by STAT3 and STAT5 in a model of B. pertussis infection of alveolar macrophages. Front Immunol. 2023 Sep 28;14:1254276. doi: 10.3389/fimmu.2023.1254276. eCollection 2023.

Ardin C, Humez S, Leroy V, Ampere A, Bordier S, Escande F, Turlotte A, Stoven L, Nunes D, Cortot A, Gauvain C. Pursuit or discontinuation of anti-PD1 after 2 years of treatment in long-term responder patients with non-small cell lung cancer. Ther Adv Med Oncol. 2023 Sep 13;15:17588359231195600. doi: 10.1177/17588359231195600.

Mazieres J, Paik PK, Garassino MC, Le X, Sakai H, Veillon R, Smit EF, Cortot AB, Raskin J, Viteri S, Wu YL, Yang JCH, Ahn MJ, Ma R, Zhao J, O’Brate A, Berghoff K, Bruns R, Otto G, Johne A, Felip E, Thomas M. Tepotinib Treatment in Patients With MET Exon 14-Skipping Non-Small Cell Lung Cancer: Long-term Follow-up of the VISION Phase 2 Nonrandomized Clinical Trial. JAMA Oncol. 2023 Sep 1;9(9):1260-1266. doi: 10.1001/jamaoncol.2023.1962. PMID: 37270698.

Fernandes M, Paget S, Kherrouche Z, Truong MJ, Vinchent A, Meneboo JP, Sebda S, Werkmeister E, Descarpentries C, Figeac M, Cortot AB and Tulasne. D. Transforming properties of MET receptor exon 14 skipping can be recapitulated by loss of the CBL ubiquitin ligase binding site. FEBS Lett. 2023 Jul 19. doi: 10.1002/1873-3468.14702.

Delval L, Hantute-Ghesquier A, Sencio V, Flaman JM, Robil C, Angulo FS, Lipskaia L, Çobanoğlu O, Lacoste AS, Machelart A, Danneels A, Corbin M, Deruyter L, Heumel S, Idziorek T, Séron K, Sauve F, Bongiovanni A, Prévot V, Wolowczuk I, Belouzard S, Saliou JM, Gosset P, Bernard D, Rouillé Y, Adnot S, Duterque-Coquillaud M, Trottein F. Removal of senescent cells reduces the viral load and attenuates pulmonary and systemic inflammation in SARS-CoV-2-infected, aged hamsters. Nat Aging. 2023 Jul;3(7):829-845. doi: 10.1038/s43587-023-00442-w.

Tsuboi M, Herbst RS, John T, Kato T, Majem M, Grohé C, Wang J, Goldman JW, Lu S, Su WC, de Marinis F, Shepherd FA, Lee KH, Le NT, Dechaphunkul A, Kowalski D, Poole L, Bolanos A, Rukazenkov Y, Wu YL; ADAURA Investigators. Overall Survival with Osimertinib in Resected EGFR-Mutated NSCLC. N Engl J Med. 2023 Jul 13;389(2):137-147. doi: 10.1056/NEJMoa2304594. Epub 2023 Jun 4.PMID: 37272535.

L Brunet, D Alexandre, J Lee, MM Blanquer-Rossello, A Guernet, H. Chhouri, Z. Kherrouche, A. Arabo, S. Yao, D. Godefroy, J. Dehedin, J. Li, C. Duparc, P. Jamme, A. Vinchent, C. Berard, D. Tulasne, S. Arena, A. Bardelli, C. Cheng, B. Chul Cho, C. Coulouarn, S. Aaronson, AB. Cortot, Y. Anouar, L. Grumolato. Prolonging lung cancer response to EGFR inhibition by targeting the selective advantage of resistant cells. bioRxiv, 2023.06. 19.545595

Baudry AS, Charton E, Piessen G, Vanlemmens L, Cortot A, Ceban T, Anota A, Christophe V. Emotional distress, supportive care needs and age in the prediction of quality of life of cancer patients’ caregivers: A cross-sectional study. Eur J Oncol Nurs. 2023 Jun;64:102324. doi: 10.1016/j.ejon.2023.102324.

Fernandes M, Hoggard B, Jamme P, Paget S, Truong MJ, Grégoire V, Vinchent A, Descarpentries C, Morabito A, Stanislovas J, Farage E, Meneboo JP, Sebda S, Bouchekioua-Bouzaghou K, Nollet M, Humez S, Perera T, Fromme P, Grumolato L, Figeac M, Copin MC, Tulasne D, Cortot AB, Kermorgant S, Kherrouche Z. MET exon 14 skipping mutation is a hepatocyte growth factor (HGF)-dependent oncogenic driver in vitro and in humanised HGF knock-in mice. Mol Oncol. 2023 Feb 17. doi: 10.1002/1878-0261.13397.

Bogard G, Barthelemy J, Hantute-Ghesquier A, Sencio V, Brito-Rodrigues P, Séron K, Robil C, Flourens A, Pinet F, Eberlé D, Trottein F, Duterque-Coquillaud M, Wolowczuk I. SARS-CoV-2 infection induces persistent adipose tissue damage in aged golden Syrian hamsters. Cell Death Dis. 2023 Feb 1;14(2):75. doi: 10.1038/s41419-023-05574-w.

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2022

Mushtaq R, Cortot AB, Gautschi O, Mazieres J, Camidge DR. PD-1/PD-L1 inhibitor activity in patients with gene-rearrangement positive non-small cell lung cancer-an IMMUNOTARGET case series.  Transl Lung Cancer Res. 2022 Dec;11(12):2412-2417. doi: 10.21037/tlcr-22-329.

Christophe V, Anota A, Vanlemmens L, Cortot AB, Ceban T, Piessen G, Charton E, Baudry AS. Unmet supportive care needs of caregivers according to medical settings of cancer patients: a cross-sectional study. Support Care Cancer. 2022 Nov;30(11):9411-9419. doi: 10.1007/s00520-022-07379-7.

Debieuvre D, Molinier O, Falchero L, Locher C, Templement-Grangerat D, Meyer N, Morel H, Duval Y, Asselain B, Letierce A, Trédaniel J, Auliac JB, Bylicki O, Moreau L, Fore M, Corre R, Couraud S, Cortot AB; Study Group KBP-2020-CPHG; KBP-2020-CPHG. Lung cancer trends and tumor characteristic changes over 20 years (2000-2020): Results of three French consecutive nationwide prospective cohorts’ studies. Lancet Reg Health Eur. 2022 Aug 29;22:100492. doi: 10.1016/j.lanepe.2022.100492.

Veillon R, Sakai H, Le X, Felip E, Cortot AB, Smit EF, Park K, Griesinger F, Britschgi C, Wu YL, Melosky B, Baijal S, Jr GC, Sedova M, Berghoff K, Otto G, Paik PK. Safety of Tepotinib in Patients With MET Exon 14 Skipping NSCLC and Recommendations for Management. Clin Lung Cancer. 2022 Jun;23(4):320-332. doi: 10.1016/j.cllc.2022.03.002.

Baldacci S, Besse B, Avrillon V, Mennecier B, Mazieres J, Dubray-Longeras P, Cortot AB, Descourt R, Doubre H, Quantin X, Duruisseaux M, Monnet I, Moro-Sibilot D, Cadranel J, Clément-Duchêne C, Cousin S, Ricordel C, Merle P, Otto J, Schneider S, Langlais A, Morin F, Westeel V, Girard N. Lorlatinib for advanced anaplastic lymphoma kinase-positive non-small cell lung cancer: Results of the IFCT-1803 LORLATU cohort. Eur J Cancer. 2022 May;166:51-59. doi: 10.1016/j.ejca.2022.01.018.

Cortot AB, Le X, Smit E, Viteri S, Kato T, Sakai H, Park K, Camidge DR, Berghoff K, Vlassak S, Paik PK. Safety of MET Tyrosine Kinase Inhibitors in Patients With MET Exon 14 Skipping Non-small Cell Lung Cancer: A Clinical Review. Clin Lung Cancer. 2022 May;23(3):195-207. doi: 10.1016/j.cllc.2022.01.003.

Sebai M, Tulasne D, Caputo SM, Verkarre V, Fernandes M, Guérin C, Reinhart F, Adams S, Maugard C, Caron O, Guillaud-Bataille M, Berthet P, Bignon YJ, Bressac-de Paillerets B, Burnichon N, Chiesa J, Giraud S, Lejeune S, Limacher JM, de Pauw A, Stoppa-Lyonnet D, Zattara-Cannoni H, Deveaux S, Lidereau R, Richard S, Rouleau E. Novel germline MET pathogenic variants in French patients with papillary renal cell carcinomas type I.  Hum Mutat. 2022 Mar;43(3):316-327. doi: 10.1002/humu.24313.

Sencio V, Machelart A, Robil C, Benech N, Hoffmann E, Galbert C, Deryuter L, Heumel S, Hantute-Ghesquier A, Flourens A, Brodin P, Infanti F, Richard V, Dubuisson J, Grangette C, Sulpice T, Wolowczuk I, Pinet F, Prévot V, Belouzard S, Briand F, Duterque-Coquillaud M, Sokol H, Trottein F. Alteration of the gut microbiota following SARS-CoV-2 infection correlates with disease severity in hamsters. Gut Microbes. 2022 Jan-Dec;14(1):2018900. doi: 10.1080/19490976.2021.2018900.

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2021

Palma M, Leroy C, Salomé-Desnoulez S, Werkmeister E, Kong R, Mongy M, Le Hir H, Lejeune F. A role for AKT1 in nonsense-mediated mRNA decay. Nucleic Acids Res. 2021 Nov 8;49(19):11022-11037. doi: 10.1093/nar/gkab882.

Le X, Sakai H, Felip E, Veillon R, Garassino MC, Raskin J, Cortot AB, Viteri S, Mazieres J, Smit EF, Thomas M, Iams WT, Cho BC, Kim HR, Yang JC, Chen YM, Patel JD, Bestvina CM, Park K, Griesinger F, Johnson M, Gottfried M, Britschgi C, Heymach J, Sikoglu E, Berghoff K, Schumacher KM, Bruns R, Otto G, Paik PK. Tepotinib Efficacy and Safety in Patients with MET Exon 14 Skipping NSCLC: Outcomes in Patient Subgroups from the VISION Study with Relevance for Clinical Practice. Clin Cancer Res. 2021 Nov 17. doi: 10.1158/1078-0432.CCR-21-2733.

Vary A, Lebellec L, Di Fiore F, Penel N, Cheymol C, Rad E, El Hajbi F, Lièvre A, Edeline J, Bimbai AM, Le Deley MC, Turpin A. FOLFIRINOX relative dose intensity and disease control in advanced pancreatic adenocarcinoma. Ther Adv Med Oncol. 2021 Jul 16;13:17588359211029825. doi: 10.1177/17588359211029825.

Pinquie F, Cortot AB, Chevalier LM, Morel A, Sandrini J, Guguen C, Morvan B, Molinier O. A Case Report of Successful Treatment With Crizotinib to Overcome Resistance to Osimertinib in an EGFR Mutated Non-Small-Cell Lung Cancer Patient Harboring an Acquired MET Exon 14 Mutation. Clin Lung Cancer. 2021 Jun 13:S1525-7304(21)00142-X. doi: 10.1016/j.cllc.2021.06.002.

Cortot AB, Madroszyk A, Giroux-Leprieur E, Molinier O, Quoix E, Bérard H, Otto J, Rault I, Moro-Sibilot D, Raimbourg J, Amour E, Morin F, Hureaux J, Moreau L, Debieuvre D, Morel H, Renault A, Pichon E, Huret B, Charpentier S, Denis MG, Cadranel J. First-Line Afatinib plus Cetuximab for EGFR-Mutant Non-Small Cell Lung Cancer: Results from the Randomized Phase II IFCT-1503 ACE-Lung Study. Clin Cancer Res. 2021 Aug 1;27(15):4168-4176. doi: 10.1158/1078-0432.CCR-20-4604.

Fernandes M, Jamme P, Cortot AB, Kherrouche Z, Tulasne D. When the MET receptor kicks in to resist targeted therapies. Oncogene. 2021 Jun;40(24):4061-4078. doi: 10.1038/s41388-021-01835-0.

Jeschke J, Collignon E, Al Wardi C, Krayem M, Bizet M, Jia Y, Garaud S, Wimana Z, Calonne E, Hassabi B, Morandini R, Deplus R, Putmans P, Dube G, Singh NK, Koch A, Shostak K, Rizzotto L, Ross RL, Desmedt C, Bareche Y, Rothé F, Lehmann-Che J, Duterque-Coquillaud M, Leroy X, Menschaert G, Teixeira L, Guo M, Limbach PA, Close P, Chariot A, Leucci E, Ghanem G, Yuan BF, Willard-Gallo K, Sotiriou C, Marine JC, Fuks F. Downregulation of the FTO m⁶A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nat Cancer. 2021 Jun;2(6):611-628. doi: 10.1038/s43018-021-00223-7.

Vauléon E, Behal H, Lebellec L, Desbarbieux R, Baldacci S, Simon N, Pannier D, Vieillard MH, Turpin A. Does bevacizumab increase joint pain in patients with cancer? Results of the prospective observational BEVARTHRALGIA study. Cancer Chemother Pharmacol. 2021 Apr;87(4):533-541. doi: 10.1007/s00280-020-04226-6.

Palma M, Lejeune F. Deciphering the molecular mechanism of stop codon readthrough. Biol Rev Camb Philos Soc. 2021 Feb;96(1):310-329. doi: 10.1111/brv.12657. Epub 2020 Oct 22. PMID: 33089614.

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2020

Duplaquet L, Leroy C, Vinchent A, Paget S, Lefebvre J, Vanden Abeele F, Lancel S, Giffard F, Bidaux G, Heliot L, Poulain L, Furlan A and Tulasne D. Control of cell death/survival balance by the MET dependence receptor. Elife. 2020 Feb 24;9.

Jamme P, Fernandes M, Copin MC, Descarpentries C, Escande F, Morabito A, Grégoire V, Jamme M, Baldacci S, Tulasne D, Kherrouche Z, and Cortot AB. Alterations in the PI3K pathway drive resistance to MET inhibitors in NSCLC harboring MET exon 14 skipping mutations. Journal of Thoracic Oncology. 2020 Mar 10.

Trzaska C, Amand S, Bailly C, Leroy C, Marchand V, Duvernois-Berthet E, Saliou JM, Benhabiles H, Werkmeister E, Chassat T, Guilbert R, Hannebique D, Mouray A, Neu-Yilik G, Copin MC, Moreau PA, Prévotat A, Reix P, Hubert D, Gérardin M, Adriaenssens E, Hentze M, Kulozik A, Westhof E, Tulasne D, Motorin Y, Rebuffat S and Lejeune F. 2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations. Nat Commun. 2020 In Press.

Baldacci S, Figeac M, Antoine M, Descarpentries C, Kherrouche Z, Jamme P, Copin MC, Tulasne D, Nanni I, Beau-Faller M, Melaabi S, Levallet G, Quoix E, Moro-Sibilot D, Friard S, Missy P, Barlesi F, Cadranel J, and Cortot AB. High MET overexpression does not predict the presence of MET exon 14 splice mutations in NSCLC : results from the IFCT Predict.amm study. Journal of Thoracic Oncology. 2020 Jan;15(1):120-124.

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2019

Duplaquet L, Figeac M, Leprêtre F, Frandemiche C, Villenet C, Sebda S, Sarafan-Vasseur N, Bénozène M, Vinchent A, Goormachtigh G, Wicquart W, Rousseau R, Beaussire L, Truant S, Michel P, Sabourin JC, Galateau F, Copin MC, Zalcman G, De Launoit Y, Fafeur V and Tulasne D. Functional analysis of somatic mutations affecting receptor tyrosine kinase family in metastatic colorectal cancer. Mol Cancer Ther. 2019 Mar 29. pii: molcanther.0582.2018.

Jamme P, Descarpentries C, Gervais R, Dansin E, Wislez M, Grégoire V, Richard N, Baldacci S, Rabbe N, Kyheng M, Kherrouche Z, Escande F, Copin MC, Cortot AB. Relevance of Detection of Mechanisms of Resistance to ALK Inhibitors in ALK-Rearranged NSCLC in Routine Practice. Clin Lung Cancer. 2019 Jul;20(4):297-304.

Turpin A, Duterque-Coquillaud M, Vieillard MH. Bone Metastasis: Current State of Play. Transl Oncol. 2019 Dec 23;13(2):308-320. Review.

Fernandes M, Duplaquet L, Tulasne D. Proteolytic cleavages of MET: the divide-and-conquer strategy of a receptor tyrosine kinase. BMB Rep. 2019 Apr;52(4):239-249. Review.

El Amrani M, Corfiotti F, Corvaisier M, Vasseur R, Fulbert M, Skrzypczyk C, Deshorgues AC, Gnemmi V, Tulasne D, Lahdaoui F, Vincent A, Pruvot FR, Van Seuningen I, Huet G, Truant S. Gemcitabine-induced epithelial-mesenchymal transition-like changes sustain chemoresistance of pancreatic cancer cells of mesenchymal-like phenotype.Mol Carcinog. 2019 Aug 2.

Gnangnon B, Fréville A, Cailliau K, Leroy C, De Witte C, Tulasne D, Martoriarti A, Jung V, Guerrera IC, Marion S, Khalife J, Pierrot C. Plasmodium pseudo-Tyrosine Kinase-like binds PP1 and SERA5 and is exported to host erythrocytes. Sci Rep. 2019 May 31;9(1):8120.

Vargas G, Bouchet M, Bouazza L, Reboul P, Boyault C, Gervais M, Kan C, Benetollo C, Brevet M, Croset M, Mazel M, Cayrefourcq L, Geraci S, Vacher S, Pantano F, Filipits M, Driouch K, Bieche I, Gnant M, Jacot W, Aubin JE, Duterque-Coquillaud M, Alix-Panabières C, Clézardin P, Bonnelye E. ERRα promotes breast cancer cell dissemination to bone by increasing RANK expression in primary breast tumors. Oncogene. 2019 Feb;38(7):950-964.

Pasquier D, Le Deley M, Tresch E, Cormier L, Duterque M, Nenan S, Lartigau E. GETUG-AFU 31: a phase I/II multicentre study evaluating the safety and efficacy of salvage stereotactic radiation in patients with intraprostatic tumour recurrence after external radiation therapy-study protocol. BMJ Open. 2019 Aug 2;9(8):e026666.

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2018

Delliaux C, Tian TV], Bouchet M, Fradet A, Vanpouille N, Flourens A, Deplus R, Villers A, Leroy X, Clézardin P, de Launoit Y, Bonnelye E, Duterque-Coquillaud M. TMPRSS2:ERG gene fusion expression regulates bone markers and enhances the osteoblastic phenotype of prostate cancer bone metastases. Cancer Lett. 2018 Dec 1;438:32-43.

Dumortier M, Ladam F, Damour I, Vacher S, Bieche I, Marchand N, DeLaunoit Y, Tulasne D and Chotteau-Lelievre A. ETV4 transcription factor and MMP13 metalloprotease are interplaying actors of breast tumorigenesis. Breast Cancer Res. 2018 Jul 11;20(1):73.

Descarpentries C, Leprêtre F, Escande F, Kherrouche Z, Figeac M, Sebda S, Baldacci S, Grégoire V, Jamme P, Copin MC, Tulasne D and Cortot AB. Optimization of routine testing for MET exon 14 splice site mutations in non-small cell lung cancer patients. Journal of Thoracic Oncology, 2018 Sep 6. pii: S1556-0864(18)33038-7.

[Baldacci S, Kherrouche Z], Cockenpot V, Stoven L, , Copin M.C, Werkmeister E, Marchand N, Maéva Kyheng, Tulasne D and. Cortot A.B. MET amplification increases the metastatic spread of EGFR-mutated NSCLC. Lung Cancer, 2018 (125)57-67.

Mekki S.M, Mougel A, Vinchent A, Paquet C, Copin M.C, Leroy L, Kherrouche Z, Bonte J.P, Melnyk O, Vicogne J. and Tulasne D. Hypoxia leads to decreased autophosphorylation of the MET receptor and promotes its resistance to tyrosine kinase inhibitors. Oncotarget. 2018 Jun 5;9(43):27039-27058.

Duplaquet L, Kherrouche Z, Baldacci S, Jamme P, Cortot AB, Copin MC and Tulasne D. The multiple paths towards MET receptor addiction in cancer. Oncogene. 2018 Jun;37(24):3200-3215. Review.

Baldacci S, Kherrouche Z, Descarpentries C, Wislez M, Dansin E, Furlan A, Tulasne D, Cortot AB. MET exon 14 splicing sites mutations: A new therapeutic opportunity in lung cancer. Rev Mal Respir. 2018 Aug 31. pii: S0761-8425(18)30200-6. Review.

Hasne J, Hague F, Rodat-despoix L, Geerts D, Leroy C, Tulasne D, Ouadid-Ahidouh H and Kischpel P. Orai3 calcium channel and resistance to chemotherapy in breast cancer cells: the p53 connection. Cell Death Differ. 2018 Jan 11.

Bokhari A, Jonchere V, Lagrange A, Bertrand R, Svrcek M, Marisa L, Buhard O, Greene M, Demidova A, Jia J, Adriaenssens E, Chassat T, Biard DS, Flejou JF, Lejeune F, Duval A, Collura A. Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability. Oncogenesis. 2018 Sep 19;7(9):70;

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2017

Deplus R, Delliaux C, Marchand N, Flourens A, Vanpouille N, Leroy X, de Launoit Y, Duterque-Coquillaud M. TMPRSS2-ERG fusion promotes prostate cancer metastases in bone. Oncotarget. 2017 Feb 14;8(7):11827-11840.

Jia J, Gonzalez-Hilarion S, Werkmeister E, Lafont F, Grunert D.C., Tulasne D and. Lejeune F. PTC readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins. J Cell Sci. 2017 Jul 25. pii: jcs.198176.

Benhabiles H, Gonzalez-Hilarion S, Amand S, Bailly C, Prévotat A, Reix P, Hubert D, Adriaenssens E, Rebuffat S, Tulasne D, Lejeune F. Optimized approach for the identification of highly efficient correctors of nonsense mutations in human diseases. PLoS One. 2017 Nov 13;12(11):e0187930.

Baldacci S, Mazieres J, Tomasini P, Girard N, Guisier F, Audigier-Valette C, Monnet I, Wislez M, Pérol M, Dô P, Dansin E, Leduc C, Leprieur EG, Moro-Sibilot D, Tulasne D, Kherrouche Z, Labreuche J, Cortot AB. Outcome of EGFR-mutated NSCLC patients with MET-driven resistance to EGFR tyrosine kinase inhibitors. Oncotarget. 2017 Oct 9;8(62):105103-105114.

Lapère C, Cortot A.B, Grégoire V, Cockenpot V, Tulasne D, and Copin M.C. Preferential localization of MET expression at the invasion front and in spreading cells through alveolar spaces in non-small-cell lung carcinomas. Am J Surg Pathol. 2017 Mar;41(3):414-422.

Montagne R, Baranzelli A, Muharram G, Leroy C, Debreuck N, Kherrouche Z, Lemière A, Cortot AB and Tulasne D. Calpain cleavage of the Met receptor variant R970C generates fragment promoting epithelial cells scattering. Oncotarget. 2017 Jan 4.

Cortot A.B, Kherrouche Z, Descarpentries C, Wislez M, Baldacci S, Furlan A and Tulasne D. Exon 14 deleted MET receptor as a new biomarker and target in cancers. J Natl Cancer Inst. 2017 May 1;109(5). Review.

Lejeune F. Nonsense-mediated mRNA decay at the crossroads of many cellular pathways. BMB Rep. 2017 Apr;50(4):175-185. Review

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THESES/HDR